| From the contents:
1. Preface
Some years ago, exposition of
the general population to pyrethroids, be it through vermin-killing measures
or through gases emanating from moth- and beetle-proofed woollen carpets
or fitted woollen materials, gave rise to thorough discussions and even to
legal disputes. For example, persons affected, amongst other things, complained
about chronic nerve damage and a number of unspecific symptoms. As happens
so often, the result in this conflict of interests was a complex mix of potentially
injured persons, of insufficient scientific data and of scientific opinions.
[…] Against this background,
the Federal Ministry for Education and Research (BMBF) supported a joint research
project stipulating that the industry concerned should bear the same financial
share. […] two studies were conducted that, for the first time, were designed
to prospectively contribute in volunteers solid data covering the incorporated
impairment, the connection between exposition and impairment and possible
health hazards.This research was conducted independently, and therefore […]
the project was assessed by independent experts. […]
2. The joint project “Exposition to Pyrethroids in Indoor
Rooms“
[…] One study included persons
having carpets containing pyrethroid in their households and thus being
permanently exposed to the insecticide. […]
In order to determine the pyrethroid
concentration, the pyrethroid concentrations in the room air were measured
in the house dust of the rooms (indoor-room monitoring). In order to detect
possible pyrethroid effects on human health, the persons affected were asked
to indicate their complaints and were physically examined and subjected to
further health-related tests. These included tests of the urine for products
of the pyrethroid metabolism (bio-monitoring), of the blood along with immunological
parameters as well as possible impairment of the nervous system (neurophysiological
tests and measurement of the brain flows). All this was designed to find
answers to such questions as:
- Does the occurrence of pyrethroids
in indoor rooms lead to relevant impairment of the residents’ health?
- Is there a change in the health
condition of people exposed to pyrethroids once (vermin-killing measures)
or permanently (woollen carpets) […]?
3. […] Health impairment through permethrin from woollen
carpets and woollen fitted carpets?
[..] Basic questions of the study
- What is the extent of exposition
to permethrin in the house dust and air of indoor rooms with woollen carpets?
- What is the share of particle-borne
permethrin that reaches the lung?
- To what extent is permethrin
bioavailable from woollen carpets, i.e., can it be found as a metabolic product
in the urine of humans?
- Is there any correlation between
the concentration of permethrin in the room air and the concentration of permethrin
metabolites (degradation products)?
- Is there any correlation between
the concentration of permethrin in the room air or the permethrin metabolites
in the urine and the state of health?
4. Correlations found or not found
[..] Permethrin
in house dust and fitted carpets
- When the permethrin concentration
in the carpet fibres increases, a rising concentration is recognisable also
in the house dust.
- In contrast to the carpet-fibre
finish, permethrin can enrich in house dust. This means that the permethrin
concentration found in house dust may be higher than that in carpet fibres.
- Compared with studies recording
the “background exposition”, house dust from flats with Eulan-finished carpets
shows a markedly higher permethrin rate.
[..] Measurement of indoor-room air
- The concentration of permethrin
in the air is very low; in 19 % of all cases it is below the identification
limit.
- No significant correlation
[…] is recognisable between the concentration of permethrin in the
room air and in the house dust.
- The permethrin in the air must
be attributed to a minor continual abrasion of small carpet fibres.
[..] Biomonitoring
- The identification of permethrin
metabolites in the urine basic indicates intake of permethrin. But:
- As a rule, the concentration
of permethrin in the urine is very low and often below the identification
limit.
- The concentration of permethrin
metabolites in fitted carpets, in house dust and in the room air does not
indicate a significant correlation with the metabolite concentration in the
urine.
[..] Recording symptoms
- No significant correlation is
recognisable between the occurrence of a symptom and the permethrin concentration
in the room air.
- The concentration of permethrin
metabolites in the urine does not show a significant correlation with the
indication of symptoms.
- The type and the frequency
of the indication of symptoms may be compared with those of a comparative
study without the influence of pyrethroids.
5. Conclusion
The results of the study covering
flats equipped with Eulan-finished woollen carpets or fitted woollen carpets
may be summarised as follows:
The indoor-room monitoring
showed that the permethrin concentrations are very high in house dust. They
are, however, very low in the toxicologically relevant room air. As, in the
study under consideration, the air is the main path for the intake of permethrin,
residents can be expected to be exposed only to a minor degree.
The metabolite concentrations
in the urine determined through biomonitoring are comparable to those observed
in other studies with general population groups. Only a small part of the
samples showed values above the identification limit.
Also the frequency of the health
symptoms indicated is similar to the findings of a comparative study conducted
with persons that are not exposed to permethrin. The persons examined obviously
perceived a range of symptoms similar to those indicated in the present study.
A correlation of their state of health with the permethrin concentration
in the room air and the metabolite concentration in the urine cannot be recognised.
The question whether this applies also to very sensitive persons such as
allergics cannot be answered due to the study’s setup.
A special label for permethrin-treated
fitted woollen carpets would benefit consumers and should thus be striven
for.
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